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Ovarian Rejuvenation: PRP-Platelet-Rich Plasma



Reproductive medicine has, until recently, assumed that there are a finite number of eggs in a women’s ovaries. Two decades ago, ovarian stem cells, cells that can, in theory, become eggs, were found to exist in the ovary of women throughout their menstruating life, and beyond, changing what we know about human reproduction. It has been shown that we can take women’s own blood and blood cells from a vein, centrifuge and treat it and extract a portion of it called “Platelet-Rich Plasma”, nicknamed PRP. That concentrated portion of your blood, PRP, contains various chemical factors that can stimulate those ovarian stem cells that may cause more good or viable eggs to be available. For women who are not yet or ever comfortable using donor eggs, this ovarian stimulation may offer a chance to get the eggs needed for their baby. This process is called “PRP treatment for IVF”.

The PRP therapy process involves collecting your blood, processing it, and extracting the protein-rich plasma, then performing a PRP injection directly into the ovarian tissue. This ovarian PRP therapy is usually very uncomfortable and so we perform it under light sedation and some local anesthesia. Although there are many protocols and no consensus (as this treatment is new and not yet mainstream), it makes the most sense to do this 3 months before the intended cycle. Some programs recommend multiple treatments as their protocol. At Fertility Partnership, we perform the treatment and monitor your blood and ultrasound antral follicle counts-AFC every 2 weeks, if possible, and will repeat the protocol based on those results. Once we see changes in hormones and/or follicles we will plan your cycle.

It has also been shown in clinical studies that PRP injections with a catheter into the uterus can thicken the thin endometrium. It is believed that those factors that stimulate eggs in the ovary, and in the uterus, stimulate the cells that make the endometrium. For women who have struggled to get their lining thick enough for a transfer, this may be an answer for them.

PRP treatment for in vitro fertilization (IVF), or ovarian rejuvenation, is very low risk to the patient. PRP has been injected into humans for many reasons. it has been used for everything from nerve regeneration to planters fasciitis. The blood products are the patient’s own and infection is rare. We cover you with oral antibiotics to be safe. Pain felt by the patient is variable. Some women can have PRP therapy done without any help, but we believe that some lidocaine to the vaginal wall and some sedation make it very tolerable.

In Summary, PRP injection is safe. Low ovarian reserve (low egg reserve) should not be a reason to think ovarian rejuvenation therapy isn’t right for you. For a woman who is potentially looking at having to give up on her own ovarian reserve, we believe that this PRP treatment offers hope for a good result. Preliminary studies and anecdotal reports support the safety and the likelihood that future studies will show a clear benefit. However, in the meantime, there are women who need hope now, and so, Fertility Partnership has joined those already offering this PRP treatment in our usual fertility clinic style: keep it as inexpensive as possible without lowering success.

For information on ovarian rejuvenation therapy or other fertility treatment, call the fertility center and ask for the PRP Coordinator- Erica Voegtlin. Tel. 636-441-7770 or email Erica at    

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47 Responses
        1. Dr. Elan Simckes

          Mary, since I am the Dr. I usually do not answer questions regarding finances. Amy Fischer the office manager does that. But I will tell you that our costs are under 9000 but that does not include medications and some freezing. We typically end up significantly lower than other places while maintaining success rates that are higher than most

  1. Elizabeth

    Yes, I dream to have a baby right now. Many doctors failed to communicate with me because I am deaf then Covid pandemic was unexpected! I pray for a miracle this YEAR! 🙏🏽🙏🏽🙏🏽 Email me instead of call so I can understand better. Thank you

    1. Dr. Elan Simckes

      I would be honored to help. We could video id you read lips. Otherwisde we can text.
      What are the issues?

  2. Nicole

    I had an ectopic pregnancy on 8/20/2021 which led to emergency surgery on 8/27/2021 and haven’t conceived again since. I lost my left tube and ovary also due to that. What should I do?

    1. Dr. Elan Simckes

      I am so sorry that you are having such a hard time. It is very likely that the other tube was also injured. I believe that you should be looking at Invocell as a possible option.

    1. Dr. Elan Simckes

      I I understand but you are interested. Please call us at (636)-441-7770. We will be happy to help. My front desk does not speak Spanish however once you’re here in the office we will do well.

  3. Carmen

    I been trying to get pregnant from my boyfriend after havin two miscarriage one after another… doctors have told me that my tubes are blocked now that I can’t have no kids due to my tubes being blocked I cry every nd I pray every night for a miracle to happen I just want is one more baby can you please help me make my dream come true!

  4. Lydia

    I am 50 years old and still fertile. I am interested in PRP as an aide for achieving pregnancy. I had my first daughter at 41 and have been told I have a very unusually young reproductive system for my age. But at 50 I would like to do the PRP as a boost in my chances. Would you consider this procedure for me?

    1. Dr. Elan Simckes

      Lydia, as long as you’re not in menopause then we would consider doing that the rp procedure. We would like free to have some follicles visible and ultrasounds and measurable AntiMullerian Hormone. Feel free to call the office and schedule consultation, perhaps a phone call, I know that we are filling up for the September PRP sessions so our number is (636)-441-7770

    1. Dr. Elan Simckes

      Jocelyn, we would be delighted and honored to take care of you. I wish I could tell you that a new sign language I only know a few bad words lol. If you want to schedule an appointment and you can test my cell phone at (314)-550-7550

  5. Cheyanne Causey

    I am a 23 year old female that was diagnosed at age 18 with AML leukemia and went into remission for a little over a year then relapsed. This time at 21, I received a bone marrow transplant and that has been successful ever since. Unfortunately with the high dose chemotherapy, my ovaries have stopped producing. The good thing is I was able to retrieve some eggs before my transplant but I know that IVF doesn’t guarantee pregnancy. My dream is to be a mother and if there is any way possible to make this happen I want to do everything in my power to do so. My question is am I a PRP candidate?

    1. Dr. Elan Simckes

      I am very
      I’m actually going to invite you to catch me to my cell phone because I am interested in seeing if it is possible for you.
      One Dr. Simckes
      (314)-550-7550 Please text

    2. Aracely Hernández

      Tengo problema de quedar embarazada hace desde quince años por qué me detectaron un quiste en un ovario y viene aquí a Estados Unidos y me hice un ultrasonido vaginal y me detectaron una fibroma en mi hutero y eso ase que no pase el esperma eso me explico mi doctor

    1. Dr. Elan Simckes

      Your choices are a tubal reversal or an IVF or Invocell procedure. You should read about Invovell.
      We are hav ing excellent results in patients post tubal ligation. The cost is similar to a reversal.
      We would want to evaluate your egg supply and sperm.
      You c

  6. I Ballard

    I have endometriosis along with endometriomas on my ovaries. I’m 42 and I’m trying to get pregnant. I’ve been to a fertility specialist who said egg donation is the only way. Can you help me?

    1. Dr. Elan Simckes

      Hello, I am sorry you are dealing with this. Egg donation may in fact be the only way but I am not sure
      if that is true. Have you had an attempt to collect eggs? what is your AMH? How large are your endometriomas? ,
      The main issue is your age, but we have helped many 42 year old women. I would be honored to evaluate you. Remember, you are in no rush for donor eggs. Up until age 55 according to the ASRM.

  7. Tee

    I am 41 and have had three unexplained early miscarriages. They did all the tests and hormones are good and they just said I have a low reserve left. For now my doc recommended letrozole for a few cycles. I just tried one so far and nothing yet so I’ma try again. I can get pregnant naturally but can’t keep them. Mayb it’s my egg quality because I have other children and never had this problem. Would I be a good candidate?

  8. Sandeep

    Hi I’m 39 two failed IVF 4 failed IUI. Am I the good candidate ? I want my own baby. My doctor suggests donor egg. What should I suggest? Thanks.

  9. Aimee De Oliveira

    Can PRP be done post hysterectomy due to adenomyosis for the purpose of extracting eggs for a bio child with surrogate?

    1. Dr. Elan Simckes

      Yes, absolutely. I would meet you first to make sure by ultrasound that I have safe access to your ovaries, get some blood work.
      Remember that this creation of embryos must be done according to FDA standards in order to put the embryos in a surrogate.
      If you live out of town plan for a PRP with us and at our intake we can discuss your bigger plans.

      1. Aimee De Oliveira

        Wonderful! I do live out of town (About 8 hour drive). How many visits might I need including the initial consult to perform the PRP and prepare the embryos for surrogacy? I am at the beginning of this process and have many unanswered questions and would need to plan for the travel and time off work.

  10. MElsayed

    Dr. Simcks, do you offer EnPLAF therapy in combination with PRP? I am 41 years old, and my AMH fluctuates between 0.9-1.34. I have regular menses. I think my big problem is egg quality, and I read that PRP alone is not effective in improving age-related bad egg quality, and EnPLAF has a better outcome since it has higher concentrations of growth factors. I did IVF 3 times, and the average egg retrieval was 5-8; the first two times, only one embryo made it to the blastocyst, tested, and was abnormal. In the last cycle, three embryos made it to the blastocyst, but I didn’t test any of them. I was planning to do one more IVF cycle in the summer (I will be 42 by that time), but I was looking for something to improve my egg quality, like EnPLAF or PRP.

  11. Rene

    I am 40 with undetectable AMH level. But, still had AFC on ultrasound. Irregular menses and high FSH level. I’ve been told I am going through perimenopause or early menopause due to prior surgery for endometriosis and fibroids. One round of semi natural IVF produced one egg that fertilized and made it to blastocyst stage but tested aneuploid. I took no medicine except for a Lupron trigger shot. I was never administered Clomid or Letrozole. I live far away in another state and wouldn’t be able to be under your continuous care for infertility. But, could I just get the PRP?

    Thank you

    1. Dr. Elan Simckes

      Hello, I appreciate you reaching out to fertility partnership. Yes you can come in for the PRP. Please call backup who coordinates this. (314)-548-3052

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